Peptides for focus

A nine-amino-acid neuropeptide explored in research as an intranasal spray for social cognition, anxiety, and bonding effects. This entry reflects research-protocol intranasal microdosing only — distinct from obstetric IV oxytocin used during labor.

• May enhance affective empathy and social engagement
• Reduces self-reported social anxiety in some trials
• Studied as adjunct to exposure therapy

A synthetic tripeptide (Glu-Asp-Arg) from Khavinson's bioregulator program at the St. Petersburg Institute of Bioregulation. Animal studies report reduced ROS in cerebellar granule and PC12 cells, plus improved cognitive outcomes in prenatal hyperhomocysteinemia and Alzheimer's mouse models.

• Reduces ROS in neuronal cells (preclinical)
• Neuroprotective in oxidative-stress models
• Improved offspring cognition in prenatal stress models

An orally bioavailable, blood-brain-barrier-penetrant hexanoyl-modified analog of angiotensin IV that potentiates the hepatocyte growth factor (HGF) / c-Met system. Preclinical work reports synaptogenesis at picomolar concentrations and reversal of scopolamine-induced cognitive deficits in rodents.

• Activates HGF/c-Met synaptogenic pathway (preclinical)
• Crosses the blood-brain barrier
• Induces hippocampal spinogenesis at picomolar doses

A 28-amino-acid neuropeptide signaling through VPAC1/VPAC2 receptors. Established anti-inflammatory and immunomodulatory effects across innate and adaptive immunity. Used clinically off-label as an intranasal preparation in chronic inflammatory response syndrome (CIRS) protocols.

• Suppresses pro-inflammatory cytokine production
• Induces regulatory T-cell phenotypes
• Studied for sepsis, RA, Crohn's, MS (preclinical)