Apple Health Outcome

Peptides for hrv

17 compoundsin Regimen’s catalog are configured to track hrv via Apple Health. Each one shows the dose range, listed benefits, and every outcome it’s set up to monitor. Tap through to plan a dose with the free reconstitution calculator.

Heart rate variability and recovery

Heart rate variability is the millisecond-scale variation between heartbeats, measured at rest. Higher HRV reflects greater autonomic flexibility and is correlated with better cardiovascular and metabolic health. Apple Watch reports daily HRV (in milliseconds, typically SDNN-based) and is reasonably accurate for trend-tracking, though absolute values vary by device.

GLP-1 protocols are associated with modest HRV improvements in observational data, driven by weight loss, improved insulin sensitivity, and reduced sympathetic tone. The LEADER and SUSTAIN trials reported cardiovascular benefit with liraglutide and semaglutide but did not measure HRV directly.

GH secretagogues, TRT, and BPC-157 do not have a coherent direct HRV mechanism. Any HRV improvement on those protocols is more likely downstream of sleep quality, body composition, and resolved hormonal deficiencies.

Compounds in Regimen tracked for hrv

17 compounds

BPC-157

Body Protective Compound

Peptide

A synthetic peptide with potent tissue-healing, gut-protective, and anti-inflammatory properties. Widely used for injury recovery and gut health.

  • Accelerated tendon and ligament healing
  • Reduced joint pain and inflammation
  • Improved gut health

Tracks

Joint painEnergyHRV

TB-500

Thymosin Beta-4 fragment

Peptide

Synthetic 17–amino-acid fragment of the naturally occurring Thymosin Beta-4 protein. Drives actin polymerization, accelerates wound and soft-tissue repair, and modulates inflammation through actin sequestration in injured tissue.

  • Soft-tissue and tendon repair
  • Reduced inflammation at injury site
  • Improved range of motion in chronic injury

Tracks

Joint painEnergyHRV

CJC-1295 + Ipamorelin

GHRH / GHRP Combination

Peptide

A synergistic growth hormone releasing combination for body composition, sleep, and recovery.

  • Increased lean muscle mass
  • Reduced body fat
  • Deeper, more restorative sleep

Tracks

SleepDeep sleepBody fatEnergyHRVSleep duration

BPC-157 + TB-500

Peptide

Tracks

Joint painEnergyHRV

Ipamorelin

Peptide

Tracks

SleepDeep sleepBody fatEnergyHRVSleep duration

CJC-1295 (No DAC)

Peptide

Tracks

SleepDeep sleepBody fatEnergyHRVSleep duration

Sermorelin

GHRH (1-29) Analog

Peptide

Synthetic analog of the first 29 amino acids of growth hormone–releasing hormone. Stimulates the pituitary to release endogenous GH in pulses, preserving the natural feedback loop and avoiding suppressed pituitary axis seen with exogenous HGH.

  • Increased lean body mass
  • Deeper sleep and improved REM
  • Improved fat metabolism, especially visceral

Tracks

SleepDeep sleepBody fatEnergyHRVSleep duration

Tesamorelin

GHRH Analog (Egrifta)

Peptide

Synthetic GHRH analog (modified GHRH 1-44) FDA-approved as Egrifta for HIV-associated lipodystrophy. Selectively reduces visceral adipose tissue and modestly elevates IGF-1 with a favorable safety profile relative to exogenous HGH.

  • Visceral adipose tissue reduction
  • Improved triglyceride and lipid profile
  • Modest IGF-1 elevation

Tracks

SleepBody fatEnergyHRV

HGH / Somatropin

Recombinant Human Growth Hormone

Hormone

Recombinant DNA-derived 191-amino-acid growth hormone identical to endogenous human somatropin. FDA-approved for clinical GH deficiency (adult and pediatric); used off-label for body composition, recovery, and anti-aging. Direct hormone replacement — bypasses the pituitary axis (unlike Sermorelin/Tesamorelin).

  • Increased lean body mass
  • Visceral and subcutaneous fat loss
  • Faster recovery from training and injury

Tracks

SleepDeep sleepBody fatEnergyHRVSleep duration

Skytrofa

Lonapegsomatropin (TransCon hGH)

Hormone

Skytrofa is a once-weekly, long-acting growth hormone for children with growth hormone deficiency (GHD). Lonapegsomatropin is a prodrug that slowly releases somatropin (hGH) over 7 days, providing stable GH levels with a single weekly injection instead of daily shots.

  • Linear growth acceleration in GH-deficient children
  • Once-weekly convenience vs. daily injections
  • Stable, sustained GH/IGF-1 levels throughout the week

Tracks

SleepBody fatEnergyHRVSleep duration

Hexarelin

Peptide

Tracks

SleepDeep sleepBody fatEnergyHRVSleep duration

NAD+

Other

Tracks

EnergySleepHRV
Reference only

GHRP-6

Ghrelin Receptor GH Secretagogue

Peptide

A synthetic hexapeptide that binds the ghrelin/GHS-R1a receptor to stimulate pulsatile growth hormone release from the anterior pituitary. Researched for GH deficiency, cachexia, and tissue-protective effects; also a potent appetite stimulant.

  • Stimulates pulsatile GH and IGF-1 release
  • Increases appetite via ghrelin pathway
  • May support recovery and lean tissue

Tracks

Deep sleepEnergyHRVSleep duration

MK-677 (Ibutamoren)

Oral Ghrelin Mimetic / GH Secretagogue

Other

An orally bioavailable, non-peptide ghrelin receptor agonist that produces sustained increases in GH and IGF-1 with once-daily dosing. Taken as a capsule — no reconstitution needed. Studied for sarcopenia, GH deficiency, and recovery support.

  • Sustained 24-hour GH and IGF-1 elevation
  • Increased fat-free mass over 12 months
  • Improved stage IV and REM sleep quality

Tracks

Deep sleepSleepWeightHRVSleep duration

MK-777 (Acetamoren)

Next-gen Ghrelin Receptor Agonist (research)

Other

A research-grade non-peptide ghrelin receptor (GHS-R1a) agonist developed as a successor to MK-677. Vendor and analog modeling describe higher receptor affinity and longer half-life, but human clinical data are not yet published.

  • Reportedly higher GHS-R1a affinity than MK-677
  • Longer half-life vs. MK-677 (analog modeling)
  • Orally bioavailable like MK-677

Tracks

Deep sleepSleepHRVSleep duration
Reference only

Frequently asked questions

Do peptides directly raise HRV?

No peptide has a direct, well-documented HRV-elevating mechanism. The HRV improvements observed during peptide protocols are downstream of other changes — weight loss, improved sleep architecture, resolved hypogonadism, reduced inflammation. Tracking HRV as a recovery proxy alongside your dose log can still be useful even if the effect is indirect.

How variable is daily HRV?

Daily HRV swings by 20–40% even in stable, healthy adults. Any single day is noise. A 30-day rolling average is the smallest window that reliably shows protocol-level change, and that’s the window Regimen’s sparkline displays alongside the dose log.

Related reading

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An honest multi-protocol comparison of Regimen, PeptIQ, Shotsy, MeAgain, and the GLP-1 calculator apps.

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